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Ceritinib is an oncology drug used to treat non-small cell lung cancer (NSCLC). It is a type of tyrosine kinase inhibitor (TKI) that works by blocking the activity of certain proteins that are involved in the growth and spread of cancer cells. Ceritinib is approved for the treatment of metastatic NSCLC in patients whose tumors have a specific genetic mutation known as ALK-positive. It is also approved for the treatment of NSCLC in patients who have progressed after treatment with crizotinib, another TKI.
Ceritinib is available in tablet form and is taken orally once daily. Common side effects include nausea, vomiting, diarrhea, fatigue, and decreased appetite. More serious side effects may include liver damage, heart problems, and lung inflammation.
Ceritinib is marketed by Novartis, Daiichi Sankyo, and Eisai. Show Less Read more