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G Protein Gated Inwardly Rectifying (GIRK) channels are a family of proteins that are involved in the regulation of cell excitability and membrane potential. They are found in the plasma membrane of many cell types, including neurons, cardiac myocytes, and endocrine cells. GIRK channels are activated by G proteins, which are activated by hormones, neurotransmitters, and other extracellular signals. GIRK channels are important for the regulation of many physiological processes, including heart rate, blood pressure, and hormone secretion.
GIRK channels are an important target for drug discovery and development. Many pharmaceutical companies are researching and developing drugs that target GIRK channels for the treatment of various diseases, including cardiovascular diseases, diabetes, and neurological disorders. Companies in the GIRK channel market include AstraZeneca, GlaxoSmithKline, Merck, Pfizer, and Novartis. Show Less Read more
