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Lotronex is a prescription drug used to treat symptoms of irritable bowel syndrome with diarrhea (IBS-D) in adults. It is a serotonin type-3 receptor antagonist, which works by blocking the action of serotonin in the gut, reducing the frequency and severity of diarrhea. Lotronex is the only drug approved by the U.S. Food and Drug Administration (FDA) specifically for the treatment of IBS-D. It is part of the gastrointestinal drugs market, which includes drugs used to treat a variety of digestive disorders, such as acid reflux, ulcers, and Crohn's disease. The gastrointestinal drugs market is highly competitive, with many large pharmaceutical companies offering a variety of treatments. Some of the major players in the market include GlaxoSmithKline, Pfizer, AstraZeneca, Merck, and Novartis. Other companies, such as Allergan, Takeda, and Daiichi Sankyo, also offer products in this market. Show Less Read more