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Pigmented Villonodular Synovitis (PVNS) is a rare disorder of the synovial membrane, which is the lining of the joints. It is characterized by the formation of nodules and villi, which are small, finger-like projections. PVNS is an immune disorder, and is treated with drugs that suppress the immune system. These drugs are typically corticosteroids, non-steroidal anti-inflammatory drugs (NSAIDs), and biologic agents. Corticosteroids are used to reduce inflammation and pain, while NSAIDs are used to reduce swelling and pain. Biologic agents are used to target specific parts of the immune system, and can be used in combination with other drugs. The PVNS drug market is composed of a variety of companies, including AbbVie, Amgen, AstraZeneca, Bristol-Myers Squibb, Eli Lilly, GlaxoSmithKline, Merck, Novartis, Pfizer, and Roche. These companies produce a range of drugs for the treatment of PVNS, including corticosteroids, NSAIDs, and biologic agents. Show Less Read more