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Essentials of Genetics

  • ID: 2176924
  • Book
  • 500 Pages
  • John Wiley and Sons Ltd
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This text is a distinctive and engaging introduction to genetics for advanced undergraduates and above. Written by the author of the best–selling human genome textbook (The Human Genome, 1999), Hawley presents a concise overview of general genetics for a 10–14 week course. His selection of examples comes from all major system categories.
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Chapter 1. The concept of Inheritance.

A. Early theories of heredity.

B. The Insight of Mendel.

C. Human Pedigrees.

D. The Concept of Mutation.

Chapter 2. Meiosis as the Basis of Mendelian Inheritance.

A. Mitosis and Meiosis.

B. The Chromosome Theory of Heredity.

a. Sex chromosomes and Sex–linkage.

b. Bridges proof of the chromosome theory.

C. Meiosis in Humans.

a. The causes and consequences of aneuploidy.

Chapter 3. DNA is the Hereditary Material.

A. Early evidence: Stadler, Chargaff.

B. The Transformation proof (Avery et al.).

C. The Structure of DNA.

D. Cloning Made Simple (DNA Libraries).

Chapter 4. Gene Expression in Prokaryotes.

(The Central Dogma).

A. One gene enzyme (Beadle and Ephrussi).

a. Genes encode protein.

b. The structure of proteins.

B. Mutations result in changes in protein sequence.

C. Colinearilty of the gene and protein.

D. DNA–>RNA–>Protein.

a. The messenger hypothesis.

b. The basic mechanics of transcription.

E. Working Out the Code (Crick, Brenner, Barnett, Watts–Tobin).

a. The basic mechanics of translation.

F. The Lac Operon.

Chapter 5. Gene Expression in Eukaryotes.

A. Splicing: Introns and Exons.

B. The Eukayotic Promoter.

C. The Basics of Transcriptional Control.

Chapter 6. The Isolation and Characterization of Mutants.

A. Yeast: Cell Cycle Mutants.

B. Drosophila: Early Embryogenesis: Nusslein–Volhard.

C. Arabidopsis: Flower Structure.

Chapter 7. Mutational Analysis.

A. The Meaning of Dominance and Recessivity.

B. The Complementation test.

C. Epistasis and Pathway Mapping.

D. Suppression.

E. The Use of Mosaics.

Chapter 8. Mapping.

A. Classic Recombination Mapping.

B. The concept of DNA Polymorphism.

C. RFLP and SNP Mapping.

(The concept of PCR).

D. Positional Cloning.

Chapter 9. Functional Genomics.

A. The Structure of Genomes.

(Repetitive DNA, Heterochromatin).

B. The Structure of Chromosomal Organelles.

C. Gene Families and Homology Searches.

D. Genome Projects.

Chapter 10. How Genomes Change.

A. Mutations and Mutagenesis.

B. Transposons.

C. How Much Variability Is There?.

D. Population Genetics Made (very) Simple.

E. Genetics and Evolutionary Theory.

Appendix: Genetics and History.

A. The Re–Discovery of Mendel.

B. The Columbia Fly Room.

C. The American Eugenics Movement.

D. Elucidating the Structure of DNA.

E. The Politics of Recombinant DNA .

F. The Understanding of the Oncogene and Tumor Suppressor Genes.

G. Cloning Mammals.

H. The Odd story of Adaptive Mutation
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R. Scott Hawley is Senior Scientist at the Stowers Institute, and one of the leading geneticists in the world. He spent many years teaching and researching at University of California Davis before moving to the prestigious Stowers Institute last year. He wrote the best–selling human Genome text (The Human Genome, 1999), and will publish Advanced Genetic Analysis: Finding Meaning in a Genome with Blackwell Publishing in the fall.  In addition to his many publications, Hawley was head of the teaching group of the Genetic Society of America.
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