Clinical Proteomics. From Diagnosis to Therapy

  • ID: 2179720
  • Book
  • 694 Pages
  • John Wiley and Sons Ltd
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Unparalleled in its scope and depth, this book brings together proteomic approaches use in the discovery and development of diagnostic and prognostic biomarkers that are applicable to all clinical fields. Following an overview of state–of–the–art technologies and strategies currently being applied to clinical proteomics, the book focuses on individual diseases including cancer, diabetes, stroke and cardiopulmonary, renal and autoimmune diseases as well as clinical toxicology finishing with a discussion of the future of clinical proteomics. This new discipline in molecular medicine holds promise to revolutionize the practice of medicine and this book is a first.

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Editors Overview

PART 1: TECHNOLOGIES

Pre–analytical issues in clinical proteomic studies

Protein separation by 2DE

Protein separation : liquid chromatography

HPLC in protein discovery

IEF analysis of peptides for biomarkers analysis

Capillary electrophoresis separations for clinical proteomics

Quantitative proteomics using nanoLC with high accuracy mass spectrometry

Antibody microarrays for protein and glycan detection

Biomarker Identification: The Role of Experimental Design, Statistics, and Data Sharing

PART 2: CANCER

Applications of stable isotope tagging based quantitive proteomics in cancer research

2–D liquid seperations, protein microarrays and mass spectrometry in comprehensive analysis of PTM and biomarker discovery

Development and Use of Reversed–Phase Protein Microarrays for Clinical Applications

CDK1 and cancer: usefulness of proteomic approaches in assesment of the molecular mechanisms and efficacy of novel therapeutics

PART 3: CARDIOVASCULAR DISEASE

Diagnostic markers for monitoring heart transplant rejection

The study of microheterogeneity in human plasma proteins: applications to acute myocardial infarction

Discovery of biomarkers for cardiovascular diseases

Development of biomarker Developfment Pipeline: Search for Myocardial Ischemia Biomarkers

Albuminome as a tool for biomarker discovery

PART 4: VASCULAR DISEASES

Application of Metabolomics to Cardiovascular Biomarker and Pathway Discovery

Urinary biomarkers in diabetic nephropathy and other glomerular diseases

Pulmonary proteomics

Proteomics providing insights into major psychiatric disorders

PART 6: BIOMARKERS

Redox Proteomics Analysis of Oxidative Modified Brain Proteins in Alzheimer´s Disease and Mild Cognitive Impairment: Insights into the Progression of This Dementing Disorder

Toxicoproteomics: correlating tissue and serum proteins in liver injuries

Biomarkers for renal disease and uraemic toxins

HIV and other viral screens

PART 6: AUTOANTIBODIES AND SIGNATURE BIOMARKERS

Application of Fungal Cyclic Peptides and Metabolites

Microarray approaches to autoantibody profiling

Identification of tumor antigen–directed autoantibodies

PART 7: FUTURE

Antibody and Reverse Capture Protein Microarrays

Use of Antibody Microarrays in the Analysis of Inflammation, Autoimmunity, Viral Infection, and Cancer Metastases

The Future: Translation from Discovery to the Clinic –

Roles of HUPO and industry in biomarker discovery
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Jennifer E. Van Eyk
Michael J. Dunn
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