Vaccinology. Principles and Practice - Product Image

Vaccinology. Principles and Practice

  • ID: 2224040
  • Book
  • 552 Pages
  • John Wiley and Sons Ltd
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Covering all aspects of vaccine research and development in one volume, this authoritative resource takes a comprehensive and systematic approach to the science of vaccinology focusing not only on basic science, but also on the many stages required to commercialize and navigate the regulatory requirements for human application, both in the United States and Europe.

  • Reviews in detail the process of designing a vaccine, from the initial stages of antigen discovery to human application
  • Includes evaluation of vaccine efficacy and safety
  • Details clinical trial design, including regulatory requirements
  • Discusses the emerging field of active cellular immunotherapy

Vaccinology: Principles and Practice provides an invaluable resource for clinicians, scientific and medical researchers, lecturers and postdoctoral fellows working in the field of vaccines.

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List of Contributors viii

Preface xii

Part 1 Introduction

1 Concept and Scope of Modern Vaccines 3D. Huw Davies, Clint S. Schmidt, & Nadeem A. Sheikh

Part 2 Principles of Vaccine Design

2 Strategies to Stimulate Innate Immunity for Designing Effective Vaccine Adjuvants 15Heather L. Wilson, Scott Napper, George K. Mutwiri, Sylvia van Drunen Littel–van den Hurk, Hugh Townsend, Lorne A. Babiuk, Andrew A. Potter, & Volker Gerdts

3 Antigen Processing and Presentation by MHC Class I, II, and Nonclassical Molecules 29Antony N. Antoniou, Izabela Lenart, David B. Guiliano, & Simon J. Powis

4 Understanding the Mucosal Immune System for Better Mucosal Vaccine Design 47Janine Bilsborough & Joanne L. Viney

5 Immunologic Memory: T Cells in Humans 61Maria Candela Iglesias, Victor Appay, & Arnaud Moris

6 Immunologic Memory: B cells 79F. Eun–Hyung Lee & Iñaki Sanz

7 Utility of Mouse Models in Vaccine Design and Development 94Catharine M. Bosio, Megan MacLeod, Philippa Marrack, & Ross M. Kedl

8 Utility of Nonhuman Primate Models for Vaccines 110Preston A. Marx, Jr & Alexander F. Voevodin

Part 3 Antigen Discovery

9 Sequence–Based Computational Approaches to Vaccine Discovery and Design 133Darrick Carter

10 Antigen Discovery for Vaccines Using High–throughput Proteomic Screening Technologies 150D. Huw Davies

11 Phage Libraries 168Aaron K. Sato

Part 4 Antigen Engineering

12 Attenuated Bacterial Vaccines 181Richard W. Titball & Helen S. Atkins

13 Virus–like Particles as Antigen Scaffolds 196Bryce Chackerian & John T. Schiller

14 Recombinant MVA vaccines: Optimization, Preclinical, and Product Development 209Yper Hall & Miles W. Carroll

15 Recombinant Adenoviruses for Vaccination 224Nelson Cesar Di Paolo, Dmitry Shayakhmetov, & André Lieber

16 Recombinant Avipoxviruses 237Michael A. Skinner & Stephen M. Laidlaw

17 Intracellular Facultative Bacterial Vectors for Cancer Immunotherapy 255Patrick Guirnalda, Laurence Wood, Matthew Seavey, & Yvonne Paterson

18 Nucleic Acid Vaccination 275Britta Wahren & Margaret A. Liu

19 Artificial Antigen–presenting Cells: Large Multivalent Immunogens 286Matthew F. Mescher & Julie M. Curtsinger

Part 5 Delivery Systems

20 Transcutaneous Immunization via Vaccine Patch Delivery System 303Robert C. Seid, Jr & Gregory M. Glenn

21 Needle–free Jet Injection for Vaccine Administration 324Brian R. Sloat, Hoi K. Tran, & Zhengrong Cui

22 Oral Vaccines: An Old Need and Some New Possibilities 336Amit A. Lugade, Kalathil Suresh, & Yasmin Thanavala

23 Adjuvants: From Serendipity to Rational Discovery 348Derek T. O Hagan & Andreas Wack

24 Immunostimulatory Properties of Biodegradable Microparticles 361Fiona A. Sharp & Ed C. Lavelle

25 Co–administration of Co–stimulatory Moieties 375Carolina Arancibia–Cárcamo & Yvette Latchman

26 Toll Receptors in Relation to Adjuvant Effects 393Dipshikha Chakravortty, Amit Lahiri, & Priyanka Das

Part 6 Regulatory Considerations

27 Regulatory Issues (FDA and EMA) 403Murrium Ahmad, Victoria Byers, & Peter Wilson

Part 7 Evaluating Vaccine Efficacy

28 Immune Monitoring Design within the Developmental Pipeline for an Immunotherapeutic or Preventive Vaccine 419Sylvia Janetzki, Pedro Romero, Mario Roederer, Diane L. Bolton, & Camilla Jandus

29 Clinical Development Strategy: Nuts and Bolts 441Candida Fratazzi & Claudio Carini

30 Current Approaches to Identify and Evaluate Cancer Biomarkers for Patient Stratification 452Robert Rees, Stephanie Laversin, Cliff Murray, & Graham Ball

Part 8 Implementing Immunizations/Therapies

31 Mass Immunization Strategies 467David L. Heymann, R. Bruce Aylward, & Rudolf H. Tangermann

32 The Role of Mathematical Models in Vaccine Development and Public Health Decision Making 480Marie–Claude Boily, Marc Brisson, Benoit Mâsse, & Roy M. Anderson

33 Vaccine Safety 509John Iskander, Claudia Vellozzi, Jane Gidudu, & Robert T. Chen

Index 525

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Vaccinology provides an invaluable and authoritative resource for clinicians, scientific and medical researchers, lecturers and postdoctoral fellows working in the field of vaccines.   (Sir Read A lot, 10 May 2012)

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