Huntington Disease summarizes the most recent findings related to the disease, providing both cutting edge coverage for clinical/research specialists looking to expand their knowledge base of Huntington disease information, as well as solid groundwork for advanced students from various backgrounds (neurology, psychiatry, neuropsychology, genetics). The volume includes all major areas of Huntington disease clinical care and research, whereas many other HD texts focus solely on neurological symptoms.
This book also addresses behavioral and cognitive symptoms, brain imaging, and family dynamics and therapeutic alliances in working with individuals affected by HD. Clinical trials are covered extensively, including design considerations for therapeutic studies. The devastating nature of Huntington's disease is well appreciated throughout the neuroscience, neurology, and psychiatric communities, and a great amount of basic and clinical research is currently taking place. However, much of that occurs in isolated research silos, and it is critical that an interdisciplinary resource be developed to provide in depth information to enhance communication and collaboration. This volume in the Handbook of Clinical Neurology series is that resource.
- Includes coverage of both basic science and clinical aspects of the disease, as well as treatment, experimental therapeutics, and biomarkers
- Provides an essential resource for the non-neurologist, including necessary background for understanding the disease before making a more detailed study proposal
- Provides an interdisciplinary approach that can be applied in everyday clinic and research efforts
- Features chapters edited by leaders in the field around the globe-the broadest expert coverage available
Section 1 Basic Science 1. Genetics of Huntington disease 2. Mechanisms underlying neurodegeneration in Huntington disease: Applications to novel disease-modifying therapies
Section 2 Clinical Aspects 3. Epidemiology of Huntington disease 4. Statistical modelling of Huntington disease onset 5. The diagnosis and natural history of Huntington disease 6. Preclinical cognitive and behavioral changes in Huntington disease 7. Preclinical motor manifestations of Huntington disease 8. The highly anxious individual presenting for Huntington disease predictive genetic testing: the psychiatrist's role in assessment and counseling 9. Reproductive options for Huntington disease families 10. Genetic testing for Huntington disease
Section 3 Treatment of Huntington Disease 11. Medical treatment of behavioral manifestations of Huntington disease 12. Medical management of motor manifestations of Huntington disease 13. The role of rehabilitation therapy in Huntington disease 14. Contemporary health care for Huntington disease 15. The impact of Huntington disease on young people 16. Making a measurable difference in advanced Huntington disease care
Section 4 Experimental Therapeutics 17. New symptomatic therapies for Huntington disease 18. Motor outcome measures in Huntington disease clinical trials 19. Cognitive outcome measures in Huntington disease clinical drug trials
Section 5 Biomarkers 20. Structural imaging in premanifest and manifest Huntington disease 21. Functional imaging in Huntington disease