Chemical and Biochemical Approaches for the Study of Anesthetic Function, Part A, Volume 602 assembles new information on our understanding of anesthesia. This latest release in the series includes sections on how physical accuracy leads to biological relevance, best practices for simulating ligand-gated ion channels interacting with general anesthetics, computational approaches for studying voltage-gated ion channels modulation by general anesthetics, anesthetic parameterization, pharmacophore QSAR, QM, ONIOM, and kinetic modeling of electrophysiology data.
- We have selected the primary experts to write about each approach
- This provides one-stop shopping for all the means of addressing this complex question
- Anesthesia is enormously important as almost everybody receives it at some point
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Computational approaches 1. Physical accuracy leads to biological relevance: Best practices for simulating ligand-gated ion channels interacting with general anesthetics Grace Brannigan and Sruthi Murlidaran 2. Computational approaches for studying voltage-gated ion channels modulation by general anesthetics Vincenzo Carnevale 3. Anesthetic parameterization Jerome Henin 4. Pharmacophore QSAR, QM, ONIOM Edward Bertaccini 5. Kinetic modeling of electrophysiology data Robert Cantor
Genetics and model organisms 6. General genetic strategies Philip G. Morgan 7. Worms Margaret Sedensky 8. Flies Bruno van Swinderen 9. Tadpoles Kellie Ann Woll 10. Zebrafish Victoria Bedell and Julia Dallman 11. Mice Max Kelz
Photolabeling 12. Mass spect ID of adducts Kellie Ann Woll 13. Photolabeling protection/competition Jonathan Cohen
Xenon 14. Xenon-protein interactions Benjamin Roose and Ivan Dmochowski 15. Xenon gas delivery/recovery procedures Mervyn Maze 16. Hyperpolarized Xe-129 MRI Mitchell Albert 17. CT imaging Andrew McKinstry-Wu
Electrophysiology 18. Native system electrophysiology (slices, cells, in vivo) Boris Heifets 19. Voltage-gated ion channels (Kv, Nav) Manuel Covarrubias and Elaine Yang 20. Ligand-gated ion channels Stuart A. Forman