Written by one of the leaders in the field of solid–phase carbohydrate synthesis, this practical book covers applications ranging from vaccines to cell signaling, synthetic peptides and asymmetric synthesis. Readers will be able to speed up their carbohydrate synthesis using automation and select the right protocol to efficiently plan synthetic pathways. In addition, a whole section is devoted to case studies, while the book finishes with a conclusion and outlook for the future.
The accompanying CD contains the analytical data for carbohydrate structures for easy access.
After earning his PhD in biochemistry in 1995, Peter Seeberger carried out postdoc research with Samuel J. Danishefsky. He began his independent career at MIT in 1998 where he was appointed Firmenich Associate Professor of Chemistry in 2002. One year later he became Professor for Organic Chemistry at the Swiss Federal Institute of Technology (ETH) in Zurich, and Affiliate Professor at the Burnham Institute in La Jolla, CA. Among his many awards, he received the Edgerton Award, the Horace B. Isbell Award from the ACS and the Otto–Klung Weberbank Prize. Prof Seeberger′s research interests focus in particular on the role of complex carbohydrates and glycoconjugates in information transfer in biological systems and on the automation of solid–phase synthesis of carbohydrates and glycosaminoglycans.
Daniel B. Werz studied chemistry at the University of Heidelberg, Germany, and the University of Bristol, UK. After gaining his doctorate in physical organic chemistry he joined Peter Seeberger′s group at the ETH as a postdoc fellow in 2004. His research interests focused on the total synthesis of oligosaccharides by solution– and solid–phase methods. Since 2006 he has been an Emmy Noether junior research group leader in the field of synthetic carbohydrate chemistry at the University of Göttingen, Germany. Among several fellowships he received the Ruprecht Karls Award of the University of Heidelberg and the Klaus Grohe Award of the German Chemical Society.
Carbohydrates in Biology and Medicine
Chemical Synthesis of Carbohydrates
Automated Solid Phase Assembly of Oligosaccharides
Synthesis of Building Blocks
Synthesis of Resins and Linkers
Setup of the Automated Synthesizer
Cleavage of the Oligosaccharide from Resin and
Deprotection and Purification of the Final Product
Removal of the Protecting Groups
Analysis, Quality Control and Quantification of Synthetic Oligosaccharides
Placement of Linkers
Conclusion and Outlook