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The Biophysics of Nerve cells

  • ID: 4470768
  • Book
  • May 2019
  • Region: Global
  • 350 Pages
  • John Wiley and Sons Ltd
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Very well structured, presenting the complex topic on a readily accessible level, this book is the first to explain all the biological properties of nerve cell membranes.

Without neglecting the known theories of nerve impulse propagation, the monograph focuses on the less known features of nerve cell membranes, such as their mechanical, caloric and optical properties. Based on these properties, the author then develops an electromechanical theory of pulse propagation, offering the most plausible explanation yet for some unresolved questions regarding the effects observed during general anesthesia.

Of prime interest to the biophysical audience working on biomembranes as well for neurobiologists and everyone involved in anesthesia research. Additional features, such as summaries, textboxes and supplementary web material, also make this an excellent companion for teaching.

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Contents

1 Introduction

1.1 History of neuroscience

1.2 Nerves

1.3 Electrophysiological findings from Bernstein, Hodgkin–Huxley until today

1.3.1 Julius Bernstein

1.3.2 Curtis & Cole

1.3.3 Hodgkin & Huxley

1.3.4

1.4 Physical findings from Galvani to Tasaki

1.4.1 Galvani & Volta

1.4.2 Helmholtz

1.4.3 Wilke

1.4.4 A. V. Hill

1.4.5 Tasaki

1.5 Membrane permeability

1.5.1 protein channels

1.5.2 lipid channels

1.6 The Hodgkin–Huxley model

1.7 The electromechanical soliton model

1.8 Anesthesia

1.9 Some thoughts about the nature of a scientific theory

2 Experimental data on nerve pulse propagation

2.1 Current and voltage measurements

2.1.1 Membranes as capacitors

2.1.2 The ion selectivity of membranes

2.2 The heat production of nerve

2.3 Mechanical measurements on nerves

2.4 Optical observations

3 The electrophysiological interpretation of nerve data

3.1 The Hodgkin Huxley model

3.2 The FitzHugh–Nagumo Model .

4 Biomembrane theory

4.1 Introduction into thermodynamic

4.2 Thermodynamics of membranes

4.2.1 Membrane melting

4.3 Entropy as a potential

4.4 Fluctuations

4.5 Thermodynamics variables

4.5.1 voltage

4.5.2 pressure

5 Biomembrane composition, melting and adaptation

5.1 Composition

5.2 Biomembrane melting

6 Introduction into hydrodynamics

6.1 History

6.2 The hydrodynamic equations

6.3 Hydrodynamics of membranes

7 Solitons

7.1 History

7.2 Bussinesc solitons

8 Experimental properties of membranes

8.1 heat capacity

8.2 compressibility

8.3 sound velocity

8.3.1 sound propagation on monofilms

8.4 dispersion

9 The electromechanical theory for nerves

9.1 Solitary pulses

9.2 Pulse trains and refractory period

9.3 Stability of pulses

9.4 Pulse energy

9.5 Pulse generation

10 Permeability and Channels

10.1 History

10.2 Patch clamp and black lipid membranes

10.3 Analyzing permeability data

10.4 Channel proteins

10.4.1 Poisons

10.4.2 Mutations

10.4.3 The impossibility of temperature–sensing receptors

10.5 Lipid membrane permeability

10.5.1 Lipid membrane channels

10.5.2 Pore theories

10.5.3 Dependence on the thermodynamic variables

10.5.4 The correlation between membrane properties and protein ion channel function

10.5.5 Sub–levels and power laws

11 Anesthesia

11.1 History

11.2 General anesthestics

11.3 Meyer–Overton rule

11.4 Local anesthetics

11.4.1 What is the dfference between local and general anesthetics

11.5 The action of anesthetics on membranes

11.6 The action of anesthetics on proteins

11.7 Cantor′s model for the lateral pressure profile

11.8 Thermodynamics of anesthetics.

11.9 Clinical findings

12 Some observations about human diseases linked to thermodynamic variables.

13 Overview over electromechanical theory.
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Thomas Heimburg
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