Retrovirus-Cell Interactions provides an up-to-date review of the interactions between retroviruses and the cells they infect, offering a comprehensive understanding of how retroviruses hijack cellular factors to facilitate virus replication. Drugs targeting viral enzymes have been developed to treat HIV; the next challenge is to inhibit virus-cell interactions as next generation treatment strategies. Organized according to the retrovirus' replication cycle, this book does not focus exclusively on HIV, but rather includes important findings in other retroviral systems, including animal retroviruses, retrotransposons, and endogenous retroelements to allow broad comparisons on important commonalities and differences.
- Provides a valuable starting point for people who want to develop a detailed understanding of retroviral replication
- Includes future-thinking strategies, such as next-generation treatment and anti-retroviral therapeutics
- Features important commonalities and differences among retroviral systems
1. Retrovirus receptor interactions and entry 2. Cellular factors that regulate uncoating and reverse transcription 3. Nuclear import of the retroviral pre-integration complex 4. Nucleoporins involved in nuclear entry of retroviral proteins 5. Host interactions involved in retroviral integration 6. Transcriptional control and latency of retroviruses 7. Splicing factors in retrovirus replication 8. RNA helicases in post-transcriptional control of retroviral gene expression 9. Cellular factors in retroviral Gag and genomic RNA trafficking 10. ESCRT family members factors involved in Gag trafficking and retrovirus budding 11. Role of lipids in membrane trafficking and assembly of retroviruses 12. Cellular immune responses to retroviruses 13. Noncoding cellular RNAs in retrovirus replication 14. Cellular control of endogenous retroviruses and retroelements 15. Experimental Approaches to Identify Cellular Factors that Influence Retroviral Replication
Physician, Professor of Medicine, Co-Director of the MD/PhD Program, Co-Leader of the Penn State CTSI Pilot and Collaborative Translational and Clinical Studies
Penn State College of Medicine