Retrovirus-Cell Interactions provides an up-to-date review of the interactions between retroviruses and the cells they infect, offering a comprehensive understanding of how retroviruses hijack cellular factors to facilitate virus replication. Drugs targeting viral enzymes have been developed to treat HIV; the next challenge is to inhibit virus-cell interactions as next generation treatment strategies. Organized according to the retrovirus' replication cycle, this book does not focus exclusively on HIV, but rather includes important findings in other retroviral systems, including animal retroviruses, retrotransposons, and endogenous retroelements to allow broad comparisons on important commonalities and differences.
- Provides a valuable starting point for people who want to develop a detailed understanding of retroviral replication
- Includes future-thinking strategies, such as next-generation treatment and anti-retroviral therapeutics
- Features important commonalities and differences among retroviral systems
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1. Retrovirus Receptor Interactions and Entry Lorraine M. Albritton 2. Cellular Factors That Regulate Retrovirus Uncoating and Reverse Transcription Stephen P. Goff 3. Nucleoporins in Retroviral Replication: What's Nup Got to Do with It? Anne Monette and Andrew J. Mouland 4. Virus-Host Interactions in Retrovirus Integration Alan N. Engelman and Goedele N. Maertens 5. Transcriptional Control and Latency of Retroviruses Bryan C. Nikolai and Andrew P. Rice 6. Teetering on the Edge: The Critical Role of RNA Processing Control During HIV-1 Replication Ahalya Balachandran, Liang Ming and Alan Cochrane 7. Nuclear RNA Helicases Support Early and Late Events in Retroviral Replication Gatikrushna Singh, Xiao Heng and Kathleen Boris-Lawrie 8. Role of Host Factors in the Subcellular Trafficking of Gag Proteins and Genomic RNA Leading to Virion Assembly Eunice C. Chen and Leslie Parent 9. Tumor Suppressor Gene 101: A Virus' Multifunctional Conduit to the ESCRT Trafficking Machinery Carol A. Carter 10. The Role of Lipids in Retroviral Replication Abdul A. Waheed and Eric O. Freed 11. Cellular Immune Responses to Retroviruses Susan R. Ross 12. Noncoding RNAs in Retrovirus Replication Alice A. Duchon and Karin Musier-Forsyth 13. Cellular Control of Endogenous Retroviruses and Retroelements Suzanne Sandmeyer 14. Strategies to Discover Novel Cellular Factors Involved in Retrovirus Replication Rebecca J. Kaddis Maldonado, Eunice C. Chen and Leslie Parent
Physician, Professor of Medicine, Co-Director of the MD/PhD Program, Co-Leader of the Penn State CTSI Pilot and Collaborative Translational and Clinical Studies
Penn State College of Medicine