Neural Stem Cells and Adult Neurogenesis provides graduate students and neuroscientists with a basic understanding of what neural stem cells are and the cell types they produce. This early graduate level reference introduces the concept of neural stem cells, describes their physiology and potential for medicine, and provides students with fundamental stem cell information to supplement or cover neuroscience or biomedical courses. An overview of stem cell sources in the human body and a brief mention of relevant diseases provide context for the value of this knowledge. The book also includes chapters on induced pluripotent stem cells (iPSCs), the methods used to obtain them, and a review of the ethical challenges associated with stem cell research. The final section focuses on adult neurogenesis in the subventricular zone and dentate gyrus. For each region the book provides a description of its neurogenic niche, cellular, and molecular biology and describes the neurons' contribution to normal and diseased brain function. The level of information is appropriate for early graduate students, introducing technology and molecular biology in an accessible format. This book will improve understanding of this fast-growing field and help the evaluation and integration of new stem cell information in the laboratory.
- Provides a basic understanding of what a stem cell is, the different types, and their potential in health and research
- Details adult neurogenesis, and its role in behavior, stroke, and disease
- Walk-through boxes illustrate experimental concepts presented in the text
- Technology boxes explain new approaches and techniques in stem cell research
Section I. Stem Cells 1. History and ethics of stem cells 2. Stem cells: From embryos to adults 3. The stem cell niche 4. Induced pluripotent stem cells
Section II. Adult Neurogenesis
The Hippocampus 5. Introduction to adult neurogenesis 6. Adult neurogenesis in the hippocampus 7. Adult neurogenesis in the subventricular zone 8. Adult neurogenesis in health and disease
Arie Mobley became interested in adult neurogenesis during her postdoctoral training at Yale University. Her research on migrating neuroblasts under normal aging conditions led to further interest in adult neurogenesis in disease states. As Assistant Professor of Neuroscience at Western New England University (WNEU) she designed an undergraduate course on stem cells and adult neurogenesis. In the search for lecture material the lack of textbook titles appropriate for undergraduates was an obstacle to providing the students with didactic information. Class discussions revealed how little familiarity the students had on these topics. Thus an idea was born with the result being the textbook, Stem Cells and Adult Neurogenesis. Her combined experiences in the lab and classroom gave her a unique perspective on what undergraduates needed to learn about stem cells and neurogenesis, and the level of information required.
Dr. Mobley received her Ph.D. at the University of Utah, Interdepartmental Neuroscience Program. Her thesis project examined the olfactory sensory neurons of the cephalopod, Lolliguncula brevis. In her postdoctoral lab at Yale University she continued to study the olfactory system focusing on activity dependent mechanisms of development. Her research has been published in journals such as J. Neurosci., J. Comp. Neurol., Trends in Neurosci., Neurobiol. Aging and PNAS. Dr. Mobley has received several grants including the Ruth Kirstein National Research Service Award (NRSA) at the graduate level under Dr. Mary T. Lucero and at the postdoctoral level under Dr. Charles Greer. She went on to obtain an NIH Small Grant Program (R03) award that was instrumental in beginning her independent research program at WNEU.