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Mechanisms of Cell Death and Opportunities for Therapeutic Development. Perspectives in Translational Cell Biology

  • Book

  • October 2021
  • Elsevier Science and Technology
  • ID: 4753527

Mechanisms of Cell Death and Opportunities for Therapeutic Development, volume four in the Perspectives in Translational Cell Biology series, offers content for professors, students and researchers across basic and translational biology. The book covers fundamental mechanisms, ranging from different forms of cell death and drug development, to efforts for treating disease, providing a valuable resource for readers interested in understanding cell death and relevant translational research. The book's editor, Diaqing Liao, has over twenty years' experience teaching topics of cell death.

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Table of Contents

1. An overview of cell death in health and disease 2. Cell death:machinery and regulation 3. Molecular mechanisms of cell death: A brief overview 4. Major methods and technologies for assessing cell death 5. Proteotoxicity and endoplasmic reticulum stress-mediated cell death 6. Protein phase separation in cell death and survival 7. Therapeutics targeting the BCL-2 pathway 8. Ferroptosis: lipids, iron, cellualar defese mechanisms and opportunities for drug development


Diaqing Liao Department of Anatomy and Cell Biology, School of Medicine, University of Florida, FL, USA. Diaing Liao has extensive experience, over twenty years, in research and teaching related to topics of cell death. He has been the course director of a graduate level course "Apoptosis� for over ten years at University of Florida. Dr. Liao's research has focused on mechanisms underlying cancer biology, epigenetic regulation and drug discovery. His lab has contributed numerous original publications on cellular and viral regulators of cell death and signalling pathways.