Mechanisms of Cell Death and Opportunities for Therapeutic Development, volume four in the Perspectives in Translational Cell Biology series, offers content for professors, students and researchers across basic and translational biology. The book covers fundamental mechanisms, ranging from different forms of cell death and drug development, to efforts for treating disease, providing a valuable resource for readers interested in understanding cell death and relevant translational research. The book's author, Diaqing Liao, has over twenty years' experience teaching topics of cell death.
- Provides a comprehensive overview of current knowledge on the process of apoptosis, its potential role in health and disease, and a discussion of potential alternative forms, such as autophagy
- Covers fundamental mechanisms and relevant translational research
1. An overview of cell death in health and disease 2. Cell death during development 3. Molecular mechanisms of apoptosis 4. Signaling pathways in cell death 5. Genetic and epigenetic regulation of cell death 6. Major methods and technologies for assessing cell death 7. Necroptosis 8. Ferroptosis 9. Autophagic cell death 10. Proteotoxicity and endoplasmic reticulum stress-mediated cell death 11. Neuronal cell death and neurodegenerative diseases 12. Cell death in metabolic diseases 13. Pathogens, inflammasome and cell death 14. Regulation of cell death in cancer 15. Mechanisms underlying drug resistance in cancer therapy 16. Immunological cell death in cancer therapy 17. Therapeutics targeting the BCL-2 pathway 18. Novel pharmacological agents targeting the inhibitors of apoptosis (IAPs) 19. Therapeutics that potentiate p53-mediated apoptosis 20. Opportunities and challenges for drug development for activating the extrinsic apoptotic pathway in cancer 22. Therapeutic approaches to prevent excessive cell death 23. Clinical studies of cancer therapeutics targeting the cell death pathways
Diaing Liao has extensive experience, over twenty years, in research and teaching related to topics of cell death. He has been the course director of a graduate level course "Apoptosis for over ten years at University of Florida. Dr. Liao's research has focused on mechanisms underlying cancer biology, epigenetic regulation and drug discovery. His lab has contributed numerous original publications on cellular and viral regulators of cell death and signalling pathways.