Cellular Signalling in Cancer Metastasis provides the reader with in-depth information on the cellular signalling mechanisms responsible for cancer metastasis. Cancer metastasis is the major cause of cancer-associated mortality. Understanding the cellular signalling mechanisms and molecules involved in cancer metastasis help devise better therapeutic interventions.
Cancer-associated deaths are mainly attributed to the dislodging of cells from the primary site of origin and establishment of colonies at distal secondary sites, termed metastasis. While there has been made significant progress in understanding the mechanisms responsible for metastasis, there is a lack of a comprehensive book compiling these aspects between one cover. This book fills that gap and provides vital information that could be exploited for the development of better therapeutics.
The book is intended to help any entry level researchers from graduation students, postdocs and early career scientists and is detailed enough to be considered by seasoned scientists. It provides the reader with the current knowledge available on the subject and stimulates others to take up investigations on understanding of cancer metastasis, as it is the cause of cancer-associated mortality and morbidity.
- Provides readers with in-depth information on the cellular signaling mechanisms responsible for cancer metastasis
- Explains the signaling pathways associated with metastasis, ranging from clinical management of metastatic disease, to a systems biology approach
- Brings together the current knowledge on signaling pathways and the mechanisms responsible for the induction and progression of metastasis, along with present therapeutic options and challenges
1. Clinical standpoint of cancer metastasis 2. Motility and tumor invasion in metastasis 3. Epithelial and mesenchymal states and their role in cancer metastasis signalling 4. Hypoxia-induced cancer metastasis signalling 5. Integrins in cancer metastases 6. miRNA mediated regulation of cancer metastasis 7. The Role of Myeloid-Derived Suppressor Cells in Cancer Progression 8. Modulation of endothelial cells for cancer metastasis 9. Vascular endothelial growth factor signalling in cancer metastasis 10. Wnt signalling in cancer metastasis 11. Notch signalling in cancer metastasis 12. GLI signalling in cancer metastasis 13. Mutant TP53 in cancer metastasis 14. CXCR4/CXCL12 in cancer metastasis 15. Role of tumor microenvironment in melanoma metastasis 16. Cancer secretome in cancer metastasis 17. Systems biology of cancer metastasis 18. Systems biology of metabolism in cancer metastasis