Phenotypic Switching: Implications in Biology and Medicine provides a comprehensive examination of phenotypic switching across biological systems, including underlying mechanisms, evolutionary significance, and its role in biomedical science. Contributions from international leaders discuss conceptual and theoretical aspects of phenotypic plasticity, its influence over biological development, differentiation, biodiversity, and potential applications in cancer therapy, regenerative medicine and stem cell therapy, among other treatments. Chapters discuss fundamental mechanisms of phenotypic switching, including transition states, cell fate decisions, epigenetic factors, stochasticity, protein-based inheritance, specific areas of human development and disease relevance, phenotypic plasticity in melanoma, prostate cancer, breast cancer, non-genetic heterogeneity in cancer, hepatitis C, and more.
This book is essential for active researchers, basic and translational scientists, clinicians, postgraduates and students in genetics, human genomics, pathology, bioinformatics, developmental biology, evolutionary biology and adaptive opportunities in yeast.
- Thoroughly addresses the conceptual, experimental and translational aspects that underlie phenotypic plasticity
- Emphasizes quantitative approaches, nonlinear dynamics, mechanistic insights and key methodologies to advance phenotypic plasticity studies
- Features a diverse range of chapter contributions from international leaders in the field
1. Quantifying Waddington landscapes and paths of cell fate decisions 2. The physics of cell fate 3. Stochastic phenotypic switching in endothelial cell heterogeneity 4. For an augmented epistemology of chance in the study of cell differentiation and development 5. Manoeuvring protein functions and functional levels by structural excursions 6. Cell-state organization by exploratory sloppy dynamics 7. Random walk across the epigenetic landscape 8. Metabolic Constraints and Phenotypic Switching: Evidence From Theory and Experiment 9. Dissecting environmentally induced and stochastic developmental phenotype variation 10. Cell differentiation in animals: metazoan-specific amplification hubs of inherent cell functions 11. Regulation of developmental plasticity from the perspective of evolutionary developmental biology 12. Phenotypic and functional variation in bird song dialects 13. Domestication as a Process Generating Phenotypic Diversity 14. Evolution by developmental scaffolding: Acquiring new phenotypes through sympoiesis 15. Bitter-Sweet Dimensions to Ovarian Cancer Progression and Metastasis 16. Phenotypic plasticity and the origins of novelty 17. Epithelial-Mesenchymal Transition in Cancer 18. Phenotypic switching and prostate diseases: A model proposing a causal link between benign prostatic hyperplasia and prostate cancer 19. Phenotypic switching and lineage switching in prostate cancer 20. Implications of non-genetic heterogeneity in cancer drug resistance and malignant progression 21. Phenotypic plasticity: the emergence of cancer stem cells and collective cell migration 22. Bistability in Virus-Host Interaction Networks Underlies the Success of Hepatitis C Treatments 23. Adaptive phenotypic switching in breast cancer in response to matrix deprivation 24. Phenotypic instability induced by tissue disruption at the origin of cancer 25. Phenotypic plasticity in fungi mediated by switches in protein conformation 26. Incorporating evolutionary dynamics of cancer to design adaptive treatment strategies
Dr. Herbert Levine is Hasselmman Professor in Bioengineering at Rice University. He is also the co-director of Center for Theoretical Biological Physics (CTBP), a National Science Foundation (NSF) Physics Frontier Center devoted to applying concepts and methods from physical sciences to complex biological and biomedical problems. He is also the coordinator of an international research network of researchers in the Physics of Living Systems, under the auspices of the NSF Science Across Virtual Institutes (SAVI) initiative. Dr. Levine did his undergraduate work at MIT, and received his Ph.D. in physics from Princeton University in 1979. After a postdoctoral fellowship at Harvard and a position on the research staff of the corporate research lab of Schlumberger Inc., he was appointed in 1987 to the faculty at the University of California, San Diego. He rose to the ranks of distinguished professor before leaving in 2012 to accept his new post at Rice. He is an elected member of the National Academy of Sciences and a fellow of the American Academy of Arts and Sciences.
Jolly, Mohit Kumar
Dr. Mohit Kumar Jolly Mohit obtained his BS and MS in Biological Sciences and Bioengineering at IIT Kanpur, India, and his Ph.D. in Bioengineering from Rice University, working at the interface of systems biology and cancer biology to decode the implications of phenotypic plasticity in cancer metastasis. He currently holds an independent postdoctoral fellowship in Computational Cancer Biology working together at Rice and MD Anderson Cancer Centre on integrating mechanistic mathematical models with high throughput clinical data to elucidate the mechanisms of metastasis. His work has been featured on the cover of the journal Molecular and Cellular Biology, and in multiple science news outlets. He also won the 2016 iBiology Young Scientist Seminar Series - a coveted award for communicating one's research to diverse audience through storytelling and visual aids.
Dr. Prakash Kulkarni is a Research Professor at the City of Hope National Medical Centre. After receiving his PhD in biochemistry from India, he completed his postdoctoral training in cell biology at New York University School of Medicine. He began his independent academic career as an Assistant Professor of urology and oncology at Johns Hopkins University School of Medicine, from where he moved to the protein biophysics laboratory at the Institute for Bioscience & Biotechnology Research at the University of Maryland, prior to taking up is current position. Prior to Johns Hopkins, Dr. Kulkarni held Staff Scientist positions in chemistry and biology at the California Institute of Technology, and in genetics at the Yale University School of Medicine. His main research interests are understanding how conformational dynamics of intrinsically disordered proteins (IDPs) contributes to non-genetic mechanisms underlying disease pathology and heterogeneity in cancer.
Dr. Vidyanand Nanjundiah is an Honorary Professor in the Center for Human Genetics, Bengaluru. He earned his BS from the University of Bombay and PhD from the University of Chicago. He held post-doctoral positions at the Hubrecht Laboratorium Utrecht, The Netherlands, Max-Planck-Institut Tubingen, Germany, and Biozentrum, Basel, Switzerland. He began his career as an Assistant Professor and rose to the rank of Professor at the Centre for Theoretical Studies, Indian Institute of Science (IISc), Bangalore. He has been a member of the Molecular Biology Unit, Tata Institute of Fundamental Research Bombay; Department of Molecular Reproduction, Development and Genetics and Centre for Ecological Sciences, Indian Institute of Science, Bangalore; and at Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore. He is an elected member of the Indian National Science Academy.