Gene Environment Interactions: Nature and Nurture in the Twenty-first Century offers a rare, synergistic view of ongoing revelations in gene environment interaction studies, drawing together key themes from epigenetics, microbiomics, disease etiology, and toxicology to illuminate pathways for clinical translation and the paradigm shift towards precision medicine. Across eleven chapters, Dr. Smith discusses interactions with the environment, human adaptations to environmental stimuli, pathogen encounters across the centuries, epigenetic modulation of gene expression, transgenerational inheritance, the microbiome's intrinsic effects on human health, and the gene-environment etiology of cardiovascular, metabolic, psychiatric, behavioral and monogenic disorders.
Later chapters illuminate how our new understanding of gene environment interactions are driving advances in precision medicine and novel treatments. In addition, the book's author shares strategies to support clinical translation of these scientific findings to improve heath literacy among the general population.
- Offers a thorough, interdisciplinary discussion on recent revelations from gene environment interaction studies
- Illuminates environmental factors affecting disease-gene etiology and treatment
- Supports the clinical translation of gene environment interaction findings into novel therapeutics and precision medicine
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1. Interacting with the environment receiving and interpreting signals 2. Environment as Provider 3. Human Evolution and adaptations to environments and to pathogen encounters 4. Genetic mechanisms in environmental adaptations 5. Epigenetics and the regulatory genome 6. The microbiome: The external life forms within 7. Human development, behaviors, impacts of environment and genetic variations 8. Joint Roles of Genes and Environment in etiology of specific diseases 9. Personalized Precision Medicine 10. Identifying and mitigating effects of Harmful factors in the Intrinsic or Extrinsic Environment 11. Questions relating to climate change
Dr. Moyra Smith is a professor emerita in the Department of Pediatrics and Human Genetics, College of Health Sciences, at the University of California, Irvine, and in past years has held appointments at the National Institutes of Health and Johns Hopkins University. In 2017, the UCI Emeriti Association awarded her the UCI Outstanding Emerita Award in recognition of her continuing research on genetics and genomics, her strong record of publications, her mentoring of graduate students, and her involvement with the CART Autism Center at UCI. She has published more than 100 scientific articles in such peer reviewed journals as Frontiers in Molecular Biosciences, Molecular Psychiatry, the American Journal of Medical Genetics-Neuropsychiatric Genetics, and the American Journal of Human Genetics.