Conjugate Addition Reactions in Organic Synthesis, Second Edition, Volume Nine provides an introduction to the chemistry of conjugate reactions, a group of reactions that constitute one of the most important classes of chemical reactions in organic synthesis. The book is organized according to class of acceptor rather than the class of nucleophile, which makes for easier synthetic problem-solving. All aspects of conjugate addition reactions are covered, including theory, mechanism, catalysis and total synthesis. Asymmetric processes are heavily featured, and there is emphasis on catalysis, given its importance in all aspects of organic synthesis today.
Extensive examples in total synthesis illustrate how particular synthetic challenges are addressed and resolved with conjugate addition chemistry. This new edition features new coverage of acceptors and nucleophiles, as well as organocatalysis, gold catalysis, peptide catalysis, arene additions, and emerging areas such as biocatalytic methods and advances in mechanism theory.
Table of Contents
1. Introduction to the conjugate addition reaction 2. Alkenals and acyclic alkenones 3. Cycloalkenones 4. Alkenoic acids and their derivatives 5. Unsaturated lactones and lactams 6. Other systems 7. Activated alkynes
Authors
Patrick Perlmutter Adjunct Professor of ChemistryLa Trobe University, Australia. Patrick Perlmutter is Adjunct Professor of Chemistry at La Trobe University in Australia. He has been a university academic for 35 years with a highly active research group specialising in synthesis and new synthetic methods including conjugate additions, catalysis, total synthesis, medicinal chemistry and chemical biology. His research group has generated approximately 200 peer-reviewed publications in that time.
