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Frontiers in Natural Product Chemistry: Volume 6

  • ID: 5174464
  • Book
  • September 2020
  • Bentham Science Publishers Ltd

Frontiers in Natural Product Chemistry is a book series devoted to publishing monographs that highlight important advances in natural product chemistry. The series covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds, including research on natural substances derived from plants, microbes and animals. Reviews of structure elucidation, biological activity, organic and experimental synthesis of natural products as well as developments of new methods are also included in the series.

The sixth volume of the series brings five reviews covering these topics:

  • Plant protein hydrolyzates from underutilized agricultural and agro-industrial sources: production, characterization and bioactive properties
  • New developments in the quinolone class of antibacterial drugs
  • Structure of fine starch prepared via a compressed hot water process
  • Major metabolites of certain marketed plant alkaloids
  • Natural products in cancer chemoprevention and chemotherapy
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Chapter 1 Plant Protein Hydrolyzates from Underutilized Agricultural and Agroindustrial Sources: Production, Characterization and Bioactive Properties

  • Introduction
  • Ways of Producing Plant Protein Hydrolyzates from Agricultural and Agroindustrial Sources
  • Sequential Extraction and Hydrolysis (Seeh)
  • Extraction by Chemical Methods and Hydrolysis
  • Extraction by Enzymatic Methods and Hydrolysis
  • Extraction by Physical/Physical-Chemical Methods and Hydrolysis
  • Simultaneous Extraction and Hydrolysis (Sieh)
  • Characterization of Protein Hydrolyzates
  • Conventional Methods
  • Polyacrylamide Gel Electrophoresis
  • Capillary Electrophoresis
  • Liquid Chromatography
  • Matrix-Assisted Laser Desorption Ionization (Maldi)-Ms
  • Others
  • Bioactive Properties of Protein Hydrolyzates and Active Peptides
  • Antioxidant Activity
  • Antihypertensive Activity
  • Diabetes Targets
  • Antimicrobial Activity
  • Other Bioactivities
  • Safety Issues
  • Conclusion
  • Patient Consent
  • Consent for Publication
  • Conflict of Interest
  • Acknowledgements
  • References

Chapter 2 New Developments in the Quinolone Class of Antibacterial Drugs

  • Introduction
  • Classification, Synthesis and Structural Requirements of Quinolone Antibacterials
  • First Generation
  • Second Generation
  • Third Generation
  • Fourth Generation
  • Synthesis of Some Quinolone Drugs
  • Rosoxacin
  • Norfloxacin, Ciprofloxacin, Fleroxacin
  • The Progress of Hybridizations in Quinolones
  • Hybridization with Azetidines
  • Hybridization with Triazole
  • Hybridization with Oxadiazole
  • Hybridization with Oxazolidinones and Thiazolidinones
  • Hybridization with Thiazole
  • Hybridization with Benzimidazole
  • Hybridization with Pyrazole
  • Oxime Functionalized 4-Quinolones
  • Chalcon Functionalized Quinolones
  • Hybridization with Metronidazole
  • Hybridization with Isatin
  • Pyrazine and Isoxacine Hybrids
  • Pyrimidine Hybrids
  • Hybridization with Flavonoids
  • Quinolone-Quinolone Conjugation
  • Amidation and Substitution by Homoaromatic Ring at C-3
  • Hybridization with Β-Lactams
  • Hybridization with Macrocycles
  • Concluding Remarks
  • Consent for Publication
  • Conflict of Interest
  • Acknowledgements
  • References

Chapter 3 Structure of Fine Starch Prepared Via a Compressed Hot Water Process

  • Introduction
  • Starch Conformation in Solid State and in Solution
  • Starch Composition and Chemical Structure
  • Preparation of Starch Nanoparticles
  • Sec-Mals, Dls, and Intrinsic Viscosity Analyses
  • Conclusion
  • Consent for Publication
  • Conflict of Interest
  • Acknowledgements
  • References

Chapter 4 Major Metabolites of Certain Marketed Plant Alkaloids

  • Introduction
  • Major Metabolites of Certain Important Marketed Alkaloids
  • Metabolite Study of Pyridine Group of Alkaloids
  • Metabolite Study of Tropane Group of Alkaloids
  • Metabolite Study of Quinoline Group of Alkaloids
  • Metabolite Study of Isoquinoline Group of Alkaloid
  • Metabolite Study of Phenanthrene Group of Alkaloid
  • Metabolite Study of Phenylethylamine Group of Alkaloids
  • Metabolite Study of Indole Group of Alkaloids
  • Metabolite Study of Purine Group of Alkaloid
  • Metabolite Study of Imidazole Group of Alkaloid
  • Metabolite Study of Terpenoid Group of Alkaloids
  • Conclusion
  • Consent for Publication
  • Conflict of Interest
  • Acknowledgements
  • References

Chapter 5 Natural Products in Cancer Chemoprevention and Chemotherapy

  • Introduction
  • Mechanism of Cancer
  • Role of Natural Products in Cancer
  • Cancer Chemoprevention
  • Cancer Chemotherapy
  • Therapeutic Mechanism of Action
  • Modulation of Diverse Transcription Factors
  • Targeting Arachidonic Acid Pathway
  • Inhibition of Estrogen Receptor Signaling
  • Targeting Telomerase
  • Promoting the Apoptosis
  • Targeting Receptors (Gfrs)
  • Interference with Microtubules
  • Inhibition of Topoisomerase
  • Combination Therapy of Nutraceutical
  • Natural Products as a Lead for Cancer Therapy
  • Conclusion
  • Consent for Publication
  • Conflict of Interest
  • Acknowledgements
  • References
  • Subject Index
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