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Hedgehog Pathway Inhibitors - Pipeline Insight, 2021

  • ID: 5262008
  • Clinical Trials
  • February 2021
  • Region: Global
  • 60 Pages
  • DelveInsight

FEATURED COMPANIES

  • Eli Lilly and Company
  • IMPACT Therapeutics
  • Pfizer
  • Pulmatrix
This “Hedgehog Pathway Inhibitors - Pipeline Insight, 2021,” report provides comprehensive insights about 10+ companies and 10+ pipeline drugs in Hedgehog Pathway Inhibitors pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Geography Covered

  • Global coverage

Hedgehog Pathway Inhibitors Understanding


Hedgehog Pathway Inhibitors: Overview


The hedgehog (Hh) signaling pathway is highly conserved in organisms ranging from insects to mammals, and plays an important role in embryogenesis and tissue homeostasis. In mammalian cells, Hh family proteins bind to the 12-transmembrane glycoprotein patched (Ptch) protein to activate the 7-transmembrane protein smoothened (Smo). Then, Smo activates transcription factors in the Gli family via formation of a cytosolic complex. Activated Gli proteins then translocate into the nucleus to induce transcription of target genes.

Aberrant activation of the Hh pathway is associated with the initiation and progression of various cancers. Blocking the Hh pathway has been reported to inhibit cancer cell growth and tumor development so the Hh signaling pathway has critical therapeutic potential.ith the JAK-STAT signaling pathway. These inhibitors have therapeutic application in the

Report Highlights

  • The companies and academics are working to assess challenges and seek opportunities that could influence Hedgehog Pathway Inhibitors R&D. The therapies under development are focused on novel approaches for Hedgehog Pathway Inhibitors.

Hedgehog Pathway Inhibitors Emerging Drugs Chapters


This segment of the Hedgehog Pathway Inhibitors report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.

Hedgehog Pathway Inhibitors Emerging Drugs

  • Glasdegib - Pfizer
Glasdegib is a oral Hedgehog pathway inhibitor. It is approved for Acute myeloid leukaemia but for indications such as Chronic myelomonocytic leukaemia, Myelofibrosis, Glioblastoma, Graft-versus-host disease, Haematological malignancies, Solid tumours it is in different phases of development.

Hedgehog Pathway Inhibitors: Therapeutic Assessment


This segment of the report provides insights about the different Hedgehog Pathway Inhibitors drugs segregated based on following parameters that define the scope of the report, such as:


Major Players working on Hedgehog Pathway Inhibitors


There are approx. 10+ key companies which are developing the Hedgehog Pathway Inhibitors. The companies which have their Hedgehog Pathway Inhibitors drug candidates in the most advanced stage, i.e. phase II include, Pfizer.

The report covers around 10+ products under different phases of clinical development like

  • Late-stage products (Phase III and
  • Mid-stage products (Phase II and
  • Early-stage products (Phase I/II and Phase I) along with the details of
  • Pre-clinical and Discovery stage candidates
  • Discontinued & Inactive candidates
  • Route of Administration

Hedgehog Pathway Inhibitors pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

  • Infusion
  • Intradermal
  • Intramuscular
  • Intranasal
  • Intravaginal
  • Oral
  • Parenteral
  • Subcutaneous
  • Topical
  • Molecule Type

Products have been categorized under various Molecule types such as

  • Vaccines
  • Monoclonal Antibody
  • Peptides
  • Polymer
  • Small molecule
  • Product Type

The drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

Hedgehog Pathway Inhibitors: Pipeline Development Activities


The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Hedgehog Pathway Inhibitors therapeutic drugs key players involved in developing key drugs.

Pipeline Development Activities


The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Hedgehog Pathway Inhibitors drugs.

Hedgehog Pathway Inhibitors Report Insights

  • Hedgehog Pathway Inhibitors Pipeline Analysis
  • Therapeutic Assessment
  • Unmet Needs
  • Impact of Drugs

Hedgehog Pathway Inhibitors Report Assessment

  • Pipeline Product Profiles
  • Therapeutic Assessment
  • Pipeline Assessment
  • Inactive drugs assessment
  • Unmet Needs

Key Questions Answered


Current Scenario and Emerging Therapies:

  • How many companies are developing Hedgehog Pathway Inhibitors drugs?
  • How many Hedgehog Pathway Inhibitors drugs are developed by each company?
  • How many emerging drugs are in mid-stage, and late-stage of development for Hedgehog Pathway Inhibitors?
  • What are the key collaborations (Industry-Industry, Industry-Academia), Mergers and acquisitions, licensing activities related to the Hedgehog Pathway Inhibitors therapeutics?
  • What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
  • What are the clinical studies going on for Hedgehog Pathway Inhibitors and their status?
  • What are the key designations that have been granted to the emerging drugs?

Key Players

  • Pfizer
  • Pulmatrix
  • Eli Lilly and Company
  • Suzhou Kintor Pharmaceuticals
  • IMPACT Therapeutics

Key Products

  • Glasdegib
  • Itraconazole inhaled
  • Taladegib
  • GT 1708F
  • IMP 5471
  • Research programme: hedgehog pathway inhibitors
Note: Product cover images may vary from those shown

FEATURED COMPANIES

  • Eli Lilly and Company
  • IMPACT Therapeutics
  • Pfizer
  • Pulmatrix

IntroductionExecutive Summary
Hedgehog Pathway Inhibitors: Overview
  • Structure
  • Mechanism of Action

Pipeline Therapeutics
  • Comparative Analysis

Therapeutic Assessment
  • Assessment by Product Type
  • Assessment by Stage and Product Type
  • Assessment by Route of Administration
  • Assessment by Stage and Route of Administration
  • Assessment by Molecule Type
  • Assessment by Stage and Molecule Type

Hedgehog Pathway Inhibitors - Analytical Perspective
In-depth Commercial Assessment
  • Hedgehog Pathway Inhibitors companies' collaborations, Licensing, Acquisition - Deal Value Trends

Hedgehog Pathway Inhibitors Collaboration Deals
  • Company-Company Collaborations (Licensing / Partnering) Analysis
  • Company-University Collaborations (Licensing / Partnering) Analysis

Mid Stage Products (Phase II)
  • Comparative Analysis

Glasdegib - Pfizer
  • Product Description
  • Research and Development
  • Product Development Activities

Early Stage Products (Phase I)
  • Comparative Analysis

Drug Name: Company Name
  • Product Description
  • Research and Development
  • Product Development Activities

Pre-clinical and Discovery Stage Products
  • Comparative Analysis

GT 1708F: Suzhou Kintor Pharmaceuticals
  • Product Description
  • Research and Development
  • Product Development Activities

Inactive Products
  • Comparative Analysis

Hedgehog Pathway Inhibitors Key CompaniesHedgehog Pathway Inhibitors Key ProductsHedgehog Pathway Inhibitors - Unmet NeedsHedgehog Pathway Inhibitors - Market Drivers and BarriersHedgehog Pathway Inhibitors - Future Perspectives and ConclusionHedgehog Pathway Inhibitors Analyst ViewsHedgehog Pathway Inhibitors Key CompaniesAppendix
List of Tables
Table 1 Total Products for Hedgehog Pathway Inhibitors
Table 2 Late Stage Products
Table 3 Mid Stage Products
Table 4 Early Stage Products
Table 5 Pre-clinical & Discovery Stage Products
Table 6 Assessment by Product Type
Table 7 Assessment by Stage and Product Type
Table 8 Assessment by Route of Administration
Table 9 Assessment by Stage and Route of Administration
Table 10 Assessment by Molecule Type
Table 11 Assessment by Stage and Molecule Type
Table 12 Inactive Products
List of Figures
Figure 1 Total Products for Hedgehog Pathway Inhibitors
Figure 2 Late Stage Products
Figure 3 Mid Stage Products
Figure 4 Early Stage Products
Figure 5 Preclinical and Discovery Stage Products
Figure 6 Assessment by Product Type
Figure 7 Assessment by Stage and Product Type
Figure 8 Assessment by Route of Administration
Figure 9 Assessment by Stage and Route of Administration
Figure 10 Assessment by Molecule Type
Figure 11 Assessment by Stage and Molecule Type
Figure 12 Inactive Products
Note: Product cover images may vary from those shown

A selection of companies mentioned in this report includes:

  • Pfizer
  • Pulmatrix
  • Eli Lilly and Company
  • Suzhou Kintor Pharmaceuticals
  • IMPACT Therapeutics
Note: Product cover images may vary from those shown