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Twin and Family Studies of Epigenetics. Translational Epigenetics Volume 27

  • Book
  • August 2021
  • Elsevier Science and Technology
  • ID: 5315165

Twin and Family Studies of Epigenetics, Volume 27, the latest release in the Translational Epigenetics series, gathers expert opinions on epigenetic twin and family study research methods, recent findings across various disease areas, and future directions. The book provides in-depth coverage of epigenetics fundamentals, twin and family epigenetic study design, and the broader role of epigenetics in answering questions on the developmental origins of health and disease. Throughout the volume, twin and family studies are employed to examine causes of epigenetic variation, the relationship between epigenetic modifications and mental illness, cancers, cardiovascular disease, diabetes, obesity, high blood pressure, and more.

Emerging research methods applied in twin and family studies discussed include imaging epigenetics, exposure-specific DNA methylation changes, and unravelling time trends in epigenetic effects.

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Table of Contents

PART 1 Introduction CHAPTER 1 Value of twin and family study designs for epigenetic research CHAPTER 2 Evaluation and measurement of epigenetic modifications in population-based studies PART 2 Human health applications CHAPTER 3 Discordant monozygotic twin studies of epigenetic mechanisms in mental health CHAPTER 4 DNA methylation and breast cancer risk: value of twin and family studies CHAPTER 5 Twin and family studies on epigenetics and oral health CHAPTER 6 Twin and family epigenetic studies of type 2 diabetes CHAPTER 7 Twin and family studies on epigenetics and obesity CHAPTER 8 DNA methylation and blood pressure in Chinese adult twins CHAPTER 9 Twin and family studies on epigenetics of autoimmune diseases CHAPTER 10 Twin studies on the epigenetics of selected neurological disorders and carotid artery disease CHAPTER 11 Disease-discordant twin studies of epigenetics and cancer CHAPTER 12 Sex differences in epigenetic profiles: The value of twin studies PART 3 Emerging approach CHAPTER 13 Combining twin-family designs with measured genetic variants to study the causes of epigenetic variation CHAPTER 14 Imaging epigenetics and the radiogenomics CHAPTER 15 DNA methylation changes specific to environmental exposures: The strengths of twin studies using cigarette smoking as an example CHAPTER 16 Time trends in epigenetic signatures and population health risks CHAPTER 17 Ambient air pollution and human epigenetic modifications


Shuai Li Centre for Epidemiology and Biostatistics, The University of Melbourne, Carlton, Australia. Dr Shuai Li has long-term experience in analyzing data from twin and family studies, including the novel epigenomic data. His PhD uses twin and family studies to research DNA methylation. He has published more than 10 papers on epigenetic epidemiological studies, specializing in twin and family designs. John Hopper Centre for Epidemiology and Biostatistics, The University of Melbourne, Carlton, Australia. Professor John Hopper, AM, was one of the nine inaugural Australia Fellows awarded by NHMRC in 2007 and is currently a NHMRC Senior Principal Research Fellow. He is a Professorial Fellow with a PhD in Mathematical Statistics, and is currently Director (Research) of the Centre for Epidemiology and Biostatistics in the School of Population Global Health at The University of Melbourne. He has published more than 700 papers, specializing in the statistical methodology and its application for analyzing twin and family data, and addressing the genetic and environmental aetiology of diseases and health. He is principal or co-investigator on a number of case-control-family studies across a range of diseases and conditions, particularly breast cancer and colorectal cancer (both funded by the National Institutes of Health (USA)), prostate cancer, melanoma, childhood cancer and asthma. He is a co-investigator on several cohort studies, including Health 2020 and long term follow-up of the 1968 Tasmanian Asthma Study. Professor Hopper has been Director of the Australian Twin Registry (Now is Twins Research Australia) since 1990 and has been awarded a NHMRC CRE grant in Twin Research in 2014.