The Neuroscience of Depression: Genetics, Cell Biology, Neurology, Behaviour and Diet is a comprehensive reference to the aspects, features and effects of depression. This book provides readers with the behavior and psychopathological effects of depression, linking anxiety, anger and PSTD to depression. Readers are provided with a detailed outline of the genetic aspects of depression including synaptic genes and the genome-wide association studies (GWAS) of depression, followed by a thorough analysis of the neurological and imaging techniques used to study depression. This book also includes three full sections on the various effects of depression, including diet, nutrition and molecular and cellular effects. The Neuroscience of Depression: Genetics, Cell Biology, Neurology, Behaviour and Diet is the only resource for researchers and practitioners studying depression.
I. Genetic Aspects of Depression 1. Epigenetics in depression 2. Genes, depression and nuclear DNA 3. Molecular aspects of postpartum depression 4. Genetics and epigenetics of the SLC6A4 gene in depression 5. Tryptophan related genes and depression 6. Metalloproteinases genes and depression 7. Linking gene regions jointly with environment and depression
II. Molecular and Cellular Effects of Depression 8. Linking depression, mRNA translation and serotonin 9. Changes in cortical gene expression in major depression: More evidence implicating inflammatory-related pathways in disease aetiology 10. FKBP5 gene expression and depression 11. Cytokines related to depression 12. Linking Interleukin-6 and Depression 13. The role of inflammatory signaling in comorbid depression and epilepsy 14. Brain inflammasomes in depression 15. Inflammatory factors and depression in substance use disorder Francisco 16. Linking Huntington disease, brain-derived neurotrophic factor and depressive-like behaviors 17. Depression and the NMDA receptor/NO/cGMP pathway 18. Translocator protein (18 kDa TSPO) binding in depression 19. Axonal transport proteins: what they are and how they relate to depressive behaviours 20. Molecular features of adenylyl cyclase isoforms and cAMP signaling: a link between adenylyl cyclase 7 and depression 21. Neurobiology of depression: the role of glycogen synthase kinase 3 22. Sortilin/NTSR3 in depression 23. Wnt/beta-catenin signaling pathway and antidepressant role 24. The prefrontal cortex in depression: use of proteomics
III. Neurological and Imaging Features 25. SPECT Neuroimaging and depression 26. Resting-state functional magnetic resonance imaging (MRI), bipolar depression and unipolar depression 27. Linking amygdala blood oxygenation-level-dependent (BOLD) activity and frontal EEG in depression 28. The rostromedial tegmental nucleus: features and links with alcohol and depression 29. Serotonergic neurons, selective serotonin reuptake inhibitor (SSRI) resistance and major depressive disorder 30. Role of nesfatin-1 in major depression 31. Impact of NGF signaling in neuroplasticity during depression: Insights in neuroplasticity dependent therapeutic approaches 32. Depression and germ cells memory
IV. Behaviour and Psychopathological Effects 33. Cognitive function and neurocognitive deficits in depression 34. Cognitive and interpersonal contributors to relationship distress and depression 35. Adolescence life stage and cognitive vulnerability to depression 36. Determining the cognitive performance in first episode of depression 37. Body image and depression 38. Sleep, anxiety and depression 39. Depression, anxiety and quality of life 40. Reward Processing and Depression: Current Findings and Future Directions 41. Sexual functioning in depressive disorders
V. Diet, Nutrition and Botanicals 42. Linking dietary glycemic index and depression 43. Gut microbiota and Depression 44. Linking dietary methyl donors, maternal separation and depression 45. Convolvulus pluricaulis usage and depression 46. Antidepressant effects of Crocus sativus (saffron) and its constituents 47. Mechanisms of action of herbal antidepressants 48. Depression, antidepressant-like effects and mechanisms of the herbal formula xiaochaihutang
VI. Resources 49. Resources in depression
Dr. Martin is a Professor of Mental Health at Buckinghamshire New University. He is a Registered Nurse, Chartered Health Psychologist, and a Chartered Scientist. He has published or has in press well over 250 research papers and book chapters. He is a keen book author and editor having written and/or edited several books all of which reflect his diverse academic and clinical interests that examine in-depth, the interface between mental health and physical health. These outputs include the Handbook of Behavior; Food and Nutrition (2011), Perinatal Mental Health: A Clinical Guide (2012); Nanomedicine and the Nervous System (2012), and the major reference works Comprehensive Guide to Autism (2014), Diet and Nutrition in Dementia and Cognitive Decline (2015), Comprehensive Guide to Post-Traumatic Stress Disorder (2016) and Metabolism and Pathophysiology of Bariatric Surgery: Nutrition, Procedures, Outcomes, and Adverse Effects (2017).
Lan-Anh Hunter Rosemead Surgery, Maidenhead, Berkshire, UK.
Dr Lan-Anh Hunter BSc MBBS DFFP DRCOG MRCGP qualified from Guys, King's & St. Thomas' Medical School, London in 2001, where she developed an early interest in psychological medicine. She went on to study culture bound syndromes, whilst reading Medical Anthropology Honours degree at University College London, focusing on the cultural aspects of anorexia nervosa in her thesis. She subsequently worked in Australia and explored the psychological aspects of diabetes and its many complications on the aboriginal population. Prior to becoming a GP Principal, she lectured at Charing Cross Hospital teaching doctors in training, continuing this passion, as a GP trainer in her current role. Much has been written about depression in primary care and hence her call to this area. She specialises in psychological medicine, with training in coaching, narrative based medicine, cognitive behaviour therapy and she continues to see, support, treat and manage clinical depression on an everyday basis as a family GP in her Maidenhead practice.
Vinood B. Patel Reader, University of Westminster, London, UK.
Dr. Patel is a Reader at the University of Westminster. After completing his PhD at King's College London, he continued his research experience by undertaking his post-doctoral studies in the laboratory of Professor Cunningham in the Department of Biochemistry at the Wake Forest University School of Medicine, (Winston-Salem, NC, USA). This extensive project involved investigating mechanisms of hepatic mitochondrial ribosome dysfunction in alcoholic liver disease (ALD) using biophysical and proteomic techniques. These studies have led to new avenues in determining the pathology of ALD. His teaching areas at both post-graduate and undergraduate levels include clinical biochemistry, investigative pathology and laboratory investigation.
Victor R. Preedy Professor of Nutritional Biochemistry, Department of Nutrition and Dietetics, Professor of Clinical Biochemistry, Department of Clinical Biochemistry; Director of the Genomics Centre, King's College, London, UK.
Dr. Preedy is a senior member of King's College London and Director of the Genomics Centre and a member of the Faculty of Life Sciences and Medicine. Professor Preedy has longstanding academic interests in substance misuse especially in relation to health and well-being. In his career Professor Preedy was Reader at the Addictive Behaviour Centre at The University of Roehampton, and also Reader at the School of Pharmacy (now part of University College London; UCL). Professor Preedy is an extremely experienced book editor, having edited influential works including but not limited to The Handbook of Alcohol Related Pathology, The Neuropathology of Drug Addictions and Substance Misuse, The Handbook of Cannabis and Related Pathologies, The Neuroscience of Cocaine, and upcoming titles The Neuroscience of Alcohol, The Neuroscience of Nicotine, and more (all Elsevier).
Rajkumar Rajendram Visiting Lecturer in the Division of Diabetes and Nutritional Sciences, King's College London, UK.
Dr. Rajendram is a clinician scientist whose focus is on perioperative medicine, anesthesia, and intensive care. He graduated in 2001 with a distinction from Guy's, King's, and St. Thomas Medical School in London, and began his postgraduate medical training in general medicine and intensive care in Oxford. Dr. Rajendram returned to Oxford as a consultant in general medicine at the John Radcliffe Hospital, Oxford, before moving to the Royal Free London Hospitals as a consultant in intensive care, anesthesia, and perioperative medicine. He is currently a consultant in internal and perioperative medicine at King Abdulaziz Medical City, Riyadh, Saudi Arabia. As a visiting lecturer in the Division of Diabetes and Nutritional Sciences, King's College London, he has published over 100 textbook chapters, review articles, peer-reviewed papers, and abstracts.