Automated Next-Generation Sequencing (NGS) Library Preparation Market Report 2026

The automated next-generation sequencing (ngs) library preparation market size has grown rapidly in recent years. It will grow from $0.72 billion in 2025 to $0.82 billion in 2026 at a compound annual growth rate (CAGR) of 13.9%. The growth in the historic period can be attributed to expansion of genomic research activities, increasing adoption of NGS in clinical research, growth of precision medicine initiatives, rising demand for scalable sequencing workflows, improvements in sequencing chemistry technologies.

The automated next-generation sequencing (ngs) library preparation market size is expected to see rapid growth in the next few years. It will grow to $1.35 billion in 2030 at a compound annual growth rate (CAGR) of 13.3%. The growth in the forecast period can be attributed to growing use of NGS in diagnostics, increasing investments in automated laboratory infrastructure, expansion of population genomics programs, rising demand for rapid sequencing turnaround times, increasing adoption of single-cell sequencing workflows. Major trends in the forecast period include increasing adoption of fully automated library preparation platforms, rising demand for high-throughput sequencing workflows, growing integration of robotics in sample processing, expansion of standardized and reproducible ngs pipelines, enhanced focus on error reduction and workflow consistency.

The increasing adoption of gene therapy is expected to drive the growth of the automated next-generation sequencing (NGS) library preparation market going forward. Gene therapy is a treatment approach that modifies a person’s genes to prevent or cure diseases. Its growth is fueled by the rising prevalence of genetic disorders that require precise and durable treatment solutions. Automated NGS library preparation supports gene therapy by enabling accurate analysis and validation of genetic modifications through the preparation of high-quality DNA or RNA samples for sequencing. For instance, in April 2024, according to the American Society of Gene and Cell Therapy, a US-based non-profit medical and scientific organization, the number of phase III gene therapy clinical trials increased by 10% in the fourth quarter of 2023, marking the first quarterly rise since Q3 2022. Therefore, the growth of gene therapy is propelling the automated next-generation sequencing (NGS) library preparation market.

Major companies in the automated next-generation sequencing (NGS) library preparation market are focusing on developing advanced technologies, such as Xpandomer technology, to enhance sequencing speed, improve data accuracy, and increase scalability, thereby streamlining workflows and supporting more efficient genomic analysis. Xpandomer technology is an advanced DNA or RNA sequencing method that converts a target nucleic acid molecule into a synthetic, expanded polymer called an Xpandomer, which is approximately 50 times longer than the original DNA or RNA strand. For instance, in February 2025, Roche AG, a Switzerland-based biotechnology company, launched Sequencing by Expansion, a state-of-the-art sequencing platform designed to enhance genomic resolution for advanced diagnostics, disease research, and precision medicine applications. This automated NGS library preparation system simplifies complex workflows, improves data quality, and accelerates genomic analysis to support cutting-edge research and personalized medicine. The Sequencing by Expansion platform is highly versatile, enabling precise analysis of diverse genomic alterations across a wide range of diseases, including cancer and rare genetic disorders, by providing higher resolution and accuracy for deeper biological insights.

In January 2023, Agilent Technologies Inc., a US-based biotechnology company, acquired Avida Biomed for an undisclosed amount. This acquisition strengthens Agilent’s cancer research and diagnostics capabilities by incorporating advanced NGS tools compatible with Agilent’s platforms. It enhances Agilent’s position in precision medicine by enabling faster, more efficient genomic analysis for applications such as biomarker discovery and therapy selection. Avida Biomed is a US-based biotechnology company specializing in high-performance NGS target enrichment workflows for cancer research.

Major companies operating in the automated next-generation sequencing (ngs) library preparation market are F. Hoffmann-La Roche Ltd., Thermo Fisher Scientific Inc., Agilent Technologies India Private Limited, Illumina Inc., Beckman Coulter Inc., Bio-Rad Laboratories Inc., IDT Corporation, Tecan Group AG, Hamilton Company, Takara Bio Inc., 10x Genomics Inc., Oxford Nanopore Technologies plc, Twist Bioscience Corporation, New England Biolabs Inc., SPT Labtech Limited, Watchmaker Genomics Inc., Pillar Biosciences Inc., Aurora Biomed Inc., BGI Group, SEQWELL INC., Hudson Robotics Inc.

North America was the largest region in the automated next-generation sequencing (NGS) library preparation market in 2025. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in the automated next-generation sequencing (ngs) library preparation market report are Asia-Pacific, South East Asia, Western Europe, Eastern Europe, North America, South America, Middle East, Africa. The countries covered in the automated next-generation sequencing (ngs) library preparation market report are Australia, Brazil, China, France, Germany, India, Indonesia, Japan, Taiwan, Russia, South Korea, UK, USA, Canada, Italy, Spain.

Tariffs are impacting the automated NGS library preparation market by increasing costs of imported robotic platforms, precision liquid handling components, consumables, reagents, and software systems. Academic and clinical laboratories in North America and Europe are most affected due to dependence on imported automation equipment, while Asia-Pacific faces cost pressures in manufacturing and export of sequencing systems. These tariffs are increasing capital investment requirements and slowing laboratory upgrades. However, they are also driving localized assembly, regional partnerships, and innovation in cost-efficient automated sequencing solutions.

The automated next-generation sequencing (ngs) library preparation market research report is one of a series of new reports that provides automated next-generation sequencing (ngs) library preparation market statistics, including automated next-generation sequencing (ngs) library preparation industry global market size, regional shares, competitors with a automated next-generation sequencing (ngs) library preparation market share, detailed automated next-generation sequencing (ngs) library preparation market segments, market trends and opportunities, and any further data you may need to thrive in the automated next-generation sequencing (ngs) library preparation industry. This automated next-generation sequencing (ngs) library preparation market research report delivers a complete perspective of everything you need, with an in-depth analysis of the current and future scenario of the industry.

Automated next-generation sequencing (NGS) library preparation refers to the use of robotic systems and software to perform the complex and repetitive steps involved in preparing DNA or RNA samples for sequencing. This process includes fragmentation, end-repair, adapter ligation, and amplification, ensuring consistency, scalability, and reduced human error in high-throughput sequencing workflows.

The primary types of automated next-generation sequencing (NGS) library preparation are targeted genome sequencing, whole genome sequencing, whole exome sequencing, and others. Targeted genome sequencing focuses on analyzing specific genomic regions of interest, offering high-depth coverage and cost-effective mutation detection for both diagnostic and research purposes. The workflow involves steps such as nucleic acid extraction, fragmentation, adapter ligation, purification, and quantification. These processes are applied across various applications, including drug and biomarker discovery, disease diagnostics, and others, and are used by end users such as hospitals and clinics, academic and research institutions, and pharmaceutical and biotechnology companies.

The automated next-generation sequencing (NGS) library preparation market consists of revenues earned by entities by providing services such as sample processing automation, quality control, and workflow optimization solutions. The market value includes the value of related goods sold by the service provider or included within the service offering. The automated next-generation sequencing (NGS) library preparation market also includes sales of workstations, robotic liquid handlers, and others. Values in this market are ‘factory gate’ values, that is the value of goods sold by the manufacturers or creators of the goods, whether to other entities (including downstream manufacturers, wholesalers, distributors and retailers) or directly to end customers. The value of goods in this market includes related services sold by the creators of the goods.

The market value is defined as the revenues that enterprises gain from the sale of goods and/or services within the specified market and geography through sales, grants, or donations in terms of the currency (in USD unless otherwise specified).

The revenues for a specified geography are consumption values that are revenues generated by organizations in the specified geography within the market, irrespective of where they are produced. It does not include revenues from resales along the supply chain, either further along the supply chain or as part of other products.

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