Glial Mechanisms in Sleep and Circadian Biology presents a comprehensive and up-to-date discussion of the role of glial cells in numerous, often unexpected, aspects of sleep. It seamlessly links glial cell activity to the multi-system processes that affect sleep. Experts in the field discuss how glial cells influence the sleep-wake cycle, the accumulation and discharge of sleep drive, the timing of sleep and wake across the 24-hour day, and how glial cells may govern important sleep functions (e.g., brain plasticity and metabolism). This is a book that could well change scientists’ and practitioners’ traditional beliefs about the factors underlying sleep.
Users will find the book's content at the forefront of one of the hottest topics in basic sleep research. Over the last decade, scientists have made breakthrough discoveries revealing that sleep is not only a product of neurons, but of neuronal-glial interactions.
Users will find the book's content at the forefront of one of the hottest topics in basic sleep research. Over the last decade, scientists have made breakthrough discoveries revealing that sleep is not only a product of neurons, but of neuronal-glial interactions.
Table of Contents
1. Introduction2. Interactions between the immune system, glia and sleep.
3. Glial chemical signaling and sleep.
4. Interactions between glia, sleep and brain metabolism.
5. Morphological and molecular changes in glia across the sleep-wake cycle.
6. Sleep-wake dependent changes in glial activity.
7. Intracellular signaling pathways in glial mediation of sleep.
8. Glial mediation of sleep: Insights from invertebrate models
9. The glymphatic system in sleep: Glial and neuronal mechanisms.
10. Glial mechanisms in circadian rhythms.
11. Glial mediation of sleep-dependent brain plasticity.
12. Conclusion
