Unlocking Sirtuins: Cellular Biology to Translational Research explores the intricate roles of sirtuins, from basic principles to clinical significance. The book is organized into six parts, covering foundational concepts, roles in aging and metabolism, disease pathology, therapeutic strategies, future research directions, and potential challenges. Topics include the structure and evolution of sirtuins, their mechanisms of action, and their impact on neurodegenerative diseases, cardiovascular health, and cancer. The book also features detailed chapters on sirtuin modulators, drug discovery, the latest technologies and tools in the field, emerging trends, and the challenges, ethical considerations and future directions of sirtuin-targeted therapies.
The book's content is complemented by case studies, clinical insights, and step-by-step procedures, offering a comprehensive and practical exploration of the subject. Users will find an in-depth overview of sirtuin biology, bridging fundamental science with clinical applications. This comprehensive resource will serve as an essential resource for researchers, clinicians, and advanced students working across cellular and molecular biology, biochemistry, pharmacology, aging, metabolic disorders, translational medicine, and related fields.
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Table of Contents
Part 1: Introduction to sirtuins1. Sirtuin proteins: structure, functions, and evolutionary insights
2. Nad?-dependent enzymatic mechanisms and NAD? precursors (NMN, NR)
Part 2: Sirtuins and aging
3. Sirtuins in senescence, mitochondrial health, and longevity
4. DNA repair and genome maintenance via sirtuin pathways
Part 3: Sirtuins in metabolic regulation
5. Sirtuins and energy homeostasis
6. Role of sirtuins in glucose and lipid metabolism
7. Sirtuins in caloric restriction and fasting responses
Part 4: Sirtuins in disease pathology 8. Sirtuins in neurodegenerative diseases
9. Sirtuins in cardiovascular health
10. The role of sirtuins in cancer progression
11. Sirtuins in inflammation and autoimmunity
Part 5: Therapeutic applications
12. Sirtuin modulators: small molecules and natural compounds
13. Sirtuin-targeted therapies: current challenges, clinical trials, and future directions
14. Translational perspectives in drug discovery
Part 6: Future directions and challenges
15. Emerging trends in sirtuin research
16. Technological advancements in sirtuin analysis
17. Experimental tools for sirtuin modulation: from CRISPR to chemical biology
18. Ethical and clinical implications of sirtuin therapies
Authors
Pranav Kumar Prabhakar Professor and Head, Department of Biotechnology, School of Engineering and Technology, Nagaland University, Meriema, Kohima, Nagaland, India.Dr. Pranav Kumar Prabhakar is currently working as a Professor and Head at Department of Biotechnology, School of Engineering and Technology, Nagaland University, Meriema, Kohima, Nagaland, India. He is among the World's Top 2% Scientists (list published by Stanford University, USA, 2021, 2022, 2023, 2024, and 2025). He completed his PhD in Biotechnology from IIT Madras. His research focuses on elucidating molecular mechanisms and strategies for oral insulin delivery and mimicking signaling pathways in metabolic disorders (diabetes) using natural products. Dr. Pranav is a member of the Royal Society of Chemistry and the Asia-Pacific Chemical, Biological & Environmental Engineering Society. He serves as an editorial board member and reviewer for many reputed national and international journals. His honors include a travel grant from IIT Madras and the Council for Scientific and Industrial Research (CSIR) to attend ATTD 2009 in Greece, approved by the Department of Science and Technology (DST). He has published over 160+ research articles, authored/edited 24 books, and 48 book chapters, and delivered 9 oral and poster presentations at scientific meetings.
Sumel Ashique Assistant Professor, Bengal College of Pharmaceutical Sciences & Research, Durgapur, West Bengal, India. Dr. Ashique is an academic in pharmaceutical sciences with experience in teaching and research, currently working as an Assistant Professor at Bengal College of Pharmaceutical Sciences & Research, Durgapur, West Bengal, India. His research and scholarly interests include drug delivery, nanotechnology, and targeted therapeutic strategies. He has authored and contributed to peer-reviewed publications and is also involved in book chapter contributions with established academic publishers. His work includes industry-oriented innovation reflected in granted patents from intellectual property and international jurisdictions.
