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Transthyretin (TTR) is a protein found in the blood and cerebrospinal fluid of humans. It is involved in the transport of thyroid hormones and retinol-binding proteins. In the context of Central Nervous System (CNS) drugs, TTR is used to treat a variety of neurological disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). TTR-based drugs are also used to treat peripheral neuropathy, a condition characterized by nerve damage in the arms and legs.
TTR-based drugs are typically administered orally or intravenously, and are designed to reduce the amount of TTR in the body. This helps to reduce the symptoms of neurological disorders, and can also slow the progression of the disease.
Several companies are involved in the development and marketing of TTR-based drugs. These include Biogen, Pfizer, and Sanofi. Other companies, such as Ionis Pharmaceuticals and Alnylam Pharmaceuticals, are involved in the research and development of new TTR-based drugs. Show Less Read more