Stem Cell Epigenetics, Eighth Edition examines how epigenetics are involved in stem cell differentiation, how a stem cell rapidly transitions into a molecularly distinct cell type, and how this process may be reversed or managed via epigenetic reprogramming. Topics discussed include chromatin in pluripotency, epigenetic regulation of reprogramming, stem cells and DNA methylation, histone modifications in stem cells and differentiation, higher-order chromatin conformation in pluripotent cells, epigenetics and disease modeling, organoids from pluripotent cells, transcriptional regulation in stem cells and differentiation, non-coding RNAs in pluripotency and early differentiation, and diseases caused by epigenetic alterations in stem cells.
Additionally, the potential implementation of stem cell epigenetics in drug discovery, regenerative medicine, and disease treatment is discussed in detail, helping researchers and physicians bring this exciting and fast evolving field to the clinic.
- Provides genetic researchers, students and physicians with evidence indicating the epigenetic mechanisms involved in stem cell differentiation
- Highlights the specific characteristics of the epigenetic modifications and misregulations that may result in disease pathogenesis
- Examines the potential application of stem cell epigenetics towards developing therapeutic interventions for disease and advancing regenerative medicine
- Features chapter contributions by leading international experts
2. Epigenetic regulation of reprogramming
3. DNA methylation regulation of stem cells
4. Histone modifications in stem cells and differentiation
5. Higher-order chromatin conformation in pluripotent cells
6. Epigenetics and disease modelling
7. Organoids from pluripotent cells
8. Transcriptional regulation in stem cells and differentiation
9. Non-coding RNAs in pluripotency and early differentiation