Developmental and Fetal Origins of Differences in Monozygotic Twins: From Genetics to Environmental Factors examines the major causes of discordance in monozygotic twins, from genetic, to environmental influences, including discussions on the genetic, epigenetic, fetal and environmental factors. Twin differences discussed include malformations, deformations and disruptions secondary to inequitable division of the early embryo, chromosome and single gene mosaicism, Nonrandom X chromosome inactivation, mitochondrial heteroplasmy, epigenetic variation, and variable and inequitable blood supply, among other influences. Differences in hemoglobin levels, placentation and amniotic fluid are also examined, while full color images illustrate discordant anomalies and twin differences throughout.
- Examines the major causes of discordance in monozygotic twins and their relevance for future studies and clinical management
- Discusses NIPT in MZ twins, twin imaging during fetal development, blood tests and forensic analysis
- Features contributions from international experts in twin genetics and developmental biology
1. The generation of MZ twins 2. Overview of the differences in MZ twins 3. Selective FGR in MZ twins 4. Differences in hemoglobin levels /TAPS 5. Epigenetics and differences in MZ twins 6. NIPT in MZ twins: does it spot the difference? 7. Placentation in MZ twins 8. Differences in amniotic fluid /TTTS 9. Differences in fetal heart in MZ twins 10. Management of discordant anomalies in MZ twins 11. TRAP sequence 12. The new imaging in MZ twins 13. Heterokaryotypic twins 14. Forensic issues in MZ twins 15. The importance of diet in MZ twins 16. Future directions in research of MZ twins
Dr. Alexandra Matias is Associate Professor of Obstetrics and Gynecology at Porto Medical School, and Senior Consultant in Obstetrics and Gynecology and Specialist in Fetal Medicine at University Hospital of S. João Porto, Portugal. Dr. Matias completed her PhD in Medicine at the University of Porto with the thesis "Venous return in the evaluation of fetal heart function, and also completed a Alexander von Humboldt Stiftung Fellowship at the Pharmakologisches Institute in Heidelberg, Germany. She currently advises 6 doctorate and 12 master's degrees in Medicine, and served as the PhD jury president at the Faculty of Medicine of the University of Barcelona. Dr. Matias has published widely in such peer reviewed journals as Twin Research and Human Genetics, Ultrasound in Obstetrics and Gynecology, the Journal of Perinatal Medicine, the Journal of Fetal Diagnosis and Therapy, and the European Journal of Pharmacology.
Isaac Blickstein is Associate Professor of Obstetrics and Gynaecology, Affiliated with the Hadassah-Hebrew University School of Medicine, Jerusalem, Israel